12 November 2015

Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses

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Viruses package their genome in a robust protein coat to protect it during transmission between cells and organisms. In a reaction termed uncoating, the virus is progressively weakened during entry into cells. At the end of the uncoating process the genome separates, becomes transcriptionally active, and initiates the production of progeny.