I studied Solid State Physics at UAM (1991-1996) and obtained my PhD in 2000 under the direction of Prof. Julio Gómez. In the meanwhile I performed three internships at Purdue University (~9 months) for studying carbon nanotubes. In the period 2001-2003 I moved to the Vrije Universiteit (Amsterdam) for a post-doc in biophysics to apply AFM for the study of microtubules and viruses at the physica van complexe systemen group. I enjoyed a Ramón y Cajal contract during 5 years and became Associate Professor in 2009. I have directed 4 PhD students and all of them stay in Academia.
Honors and Awards
- PhD Extraordinary Price.
My interest encompass the application of single-molecule techniques for material science and soft matter. Specifically, the use of Atomic Force Microscopy, either by its own or in combination with fluorescence microscopy, for studying both natural and artificial protein nanocages in liquid. On one hand, I am interested in studying the structure-function-properties interplay of individual viruses. On the other hand, my interests include the investigation of the physicochemical properties of protein shells utilized as nanocontainers for alien molecules, such as proteins, enzymes, metals, etc.
1. Tuning Viral Capsid Nanoparticle Stability with Symmetrical Morphogenesis, Aida Llauró, Benjamin Schwarz, Ranjit Koliyatt, Pedro J. de Pablo, and Trevor Douglas, ACS Nano, 10 (9), pp 8465–8473, (2016). [URL]
2. Mechanics of Viral Chromatin Reveals the Pressurization of Human Adenovirus, A. Ortega-Esteban, G. Condezo, A. J. Pérez-Berná, M. Chillón, S. J. Flint, D. Reguera, C. San Martín and P. J. de Pablo, ACS Nano, 9 (11), pp 10826–10833, (2015). [URL]
3. Fluorescence Tracking of Genome Release during Mechanical Unpacking of Single Viruses, A. Ortega-Esteban, K. Bodensiek, C. San Martín, M. Suomalainen, U. Greber, Pedro J. de Pablo and I. A. T. Schaap, ACS Nano, 9 (11), pp 10571–10579, (2015). [URL]
4. Quantitative nanoscale electrostatics of viruses, M. Hernando-Pérez, A. X. Cartagena-Rivera, A. Lošdorfer Božič, P. J. P. Carrillo, C. San Martín, M. G. Mateu, A. Raman, R. Podgornik and P. J. de Pablo, Nanoscale 7(41): 17289-17298, (2015). [URL]
5. Cementing proteins provide extra mechanical stabilization to viral cages, M. Hernando-Pérez, S. Lambert, E. Nakatani-Webster, C. E. Catalano & P. J. de Pablo, Nature Communications 5, 4520 (2014). [URL]
6. Mechanical elasticity as a physical signature of conformational dynamics in a virus particle, Milagros Castellanos, Rebeca Pérez, Carolina Carrasco, Mercedes Hernando-Pérez, Julio Gómez-Herrero, Pedro J. de Pablo, and Mauricio G. Mateu, Proceedings of the National Academy of Sciences of the United States of America 109(30): 12028-12033, (2012). [URL]
7. The capillarity of nanometric water menisci confined inside closed-geometry viral cages, C. Carrasco, M. Douas, R. Miranda, M. Castellanos, P. A. Serena, J. L. Carrascosa, M. G. Mateu, M. I. Marquésc and P. J. de Pablo, Proceedings of the National Academy of Sciences of the United States of America 106(14): 5475-5480, (2009). [URL]
8. Manipulation of the mechanical properties of a virus by protein engineering, Carolina Carrasco, Milagros Castellanos, Pedro J. de Pablo, and Mauricio G. Mateu, Proceedings of the National Academy of Sciences of the United States of America 105(11): 4150-4155, (2008). [URL]
9. DNA-mediated anisotropic mechanical reinforcement of a virus, C. Carrasco, A. Carreira, I. A. T. Schaap, P. A. Serena, J. Gómez-Herrero, M. G. Mateu, and P. J. de Pablo, Proceedings of the National Academy of Sciences of the United States of America 103(37): 13706-13711, (2006). [URL]
10. Bacteriophage capsids: Tough nanoshells with complex elastic properties, I. L. Ivanovska, P. J. de Pablo, B. Ibarra, G. Sgalari, F. C. MacKintosh, J. L. Carrascosa, C. F. Schmidt, and G. J. L. Wuite, Proceedings of the National Academy of Sciences of the United States of America 101(20): 7600-7605, (2004). [URL]